Natural tropism to the liver is a major obstacle in systemic delivery of adenoviruses in cancer gene therapy.Adenovirus binding to soluble coagulation factors and to cellular heparan sulphate proteoglycans via the fiber shaft KKTK domain are suggested to cause liver tropism.Serotype 5 adenovirus constructs with mutated KKTK regions exhibit liver de
Introduction: Stress fractures occur due to repetitive cumulative micro trauma on the bone over a period of time.Stress fractures in military cadets is a rising cause of concern.It increases morbidity, long periods of absence from training and economic losses.Aim: The purpose of this prospective study was to determine the incidence and distribution
The uterine rupture during pregnancy is a catastrophic condition resulting in both maternal and perinatal morbidity and mortality.It occurs in nearly 1% of patients with previous cesarean sections.However, uterine rupture at the site of previous iatrogenic perforation which is spontaneously healed or repaired is less reported.We present a 29-year-o
Introduction: Brazil is the second country in the world with the largest number of gyms, currently accounting for approximately 30 thousand units.There is increasing evidence that a significant part of gym-goers develop excessive commitment to practicing physical exercises, which may even generate pathological dependence.Aim: To determine the assoc